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Withdrawal
Users of hydromorphone can experience painful symptoms if the drug is suspended. Some people cannot tolerate the symptoms which result in continuous drug use. Symptoms of opioid withdrawal are not easy to decipher. There are differences between drug-seeking behaviors and true withdrawal effects. Symptoms associated with hydromorphone withdrawal include:

Abdominal pain
Anxiety/panic attacks
Depression
Goose bump skin
Inability to enjoy daily activities
Muscle and joint pain
Nausea
Runny nose and excessive secretion of tears
Sweating
Vomiting
In the clinical setting excessive secretion of tears, yawning and dilation of pupils are helpful presentations in diagnosing opioid withdrawal. Hydromorphone is a rapid acting pain killer, however some formulations can last up to several hours; patients who stop taking this drug abruptly might experience withdrawal symptoms. These can start within hours of taking the last dose of hydromorphone and can last up to several weeks. Withdrawal symptoms in people who stopped taking the opioid can be managed by using opioids or non-opioid adjuncts. Methadone is an opioid commonly used for this kind of therapy. However, the selection of therapy should be tailored to each specific person.Methadone is also used for detoxification in people who have opioid addiction such as heroin or drugs similar to morphine. It can be given orally or intramuscularly. There is controversy regarding the use of opioids for people experiencing withdrawal symptoms since these agents can themselves cause relapse on patients when they suspend therapy. Clonidine is a non-opioid adjunct that can be used in situations where opioid use is not desired, such as in patients with high blood pressure.